Download PDF by Richard M Fox: A monograph of the Ithomiidae (Lepidoptera) Part IV: The

By Richard M Fox

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Extra info for A monograph of the Ithomiidae (Lepidoptera) Part IV: The tribe Napeogenini Fox, (American Entomological Institute. Memoir)

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Also, immunizing mice with col(V) induces immunological tolerance to lung alloantigens. However, the ability of col(V) to induce oral tolerance and prevent the immunology and pathology of lung allograft rejection is unknown. Our laboratory is one of the few that developed the rat model of lung allograft rejection in which F344 rat lungs (RT1lv1) are transplanted orthotopically into WKY (RT1I) recipients. Utilizing this model, the current proposal tests the hypothesis that oral tolerance induction by col(V) prevents the immunology and pathology of lung allograft rejection by examining the following specific aims: Aim 1: To determine if oral immunization with col(V) induces oral tolerance to alloantigens and prevents the development of rejection pathology in lung allografts, rats will be fed col(V) followed by an assessment of delayed type hypersensitivity (DTH) responses to donor alloantigens, and onset of acute rejection and bronchiolitis obliterans (BO) in allograft lungs.

There are at least two mechanisms, which are not mutually exclusive, that could account for an enhanced vulnerability of post-viral airways to eosinophil-dependent effects. First, eosinophils may experience changes in their phenotypic characteristics arising from migration into, and interactions with, the altered post-viral airways. Second, structural changes in the post-viral airway environment may increase the likelihood that eosinophils will migrate into and remain in the airway walls. Therefore, studies will be performed to track the migration of labeled eosinophils (which are either instilled into the airspace of the lung or infused intravenously) into normal and post-viral airways.

The experiments will involve transgenic models of CD8* T cell-mediated autoimmune myocarditis, pancreatic islet inflammation, nephritis, and bronchiolitis. The recruitment and pathogenicity of CD8- T cells with altered selectin-ligand expression will be quantitatively compared with control T cells. Specific Aim #2 will focus on how chemokines influence recruitment of tissue antigen-specific CD8+ T cells. The underlying hypothesis is that chemokines expressed in tissues will differentially effect the recruitment of CD8+ T cells, depending on the vascular bed and the subsetphenotype of the T cells.

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A monograph of the Ithomiidae (Lepidoptera) Part IV: The tribe Napeogenini Fox, (American Entomological Institute. Memoir) by Richard M Fox


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