By Charles R. Scoggins, Chandrajit P. Raut, John T. Mullen
This textbook offers a finished, cutting-edge evaluate of this box, and may function a worthy source for clinicians, surgeons and researchers with an curiosity in GIST. The publication reports new info approximately hazard elements for the affliction, profiles the recent staging procedure for GIST, highlights our present knowing of genetic mutations that result in GIST, and offers new views approximately imaging of GIST tumors. For localized ailment, a better appreciation of organ-sparing ways and the significance of upkeep of gastrointestinal functionality is mentioned intimately, and advances in surgical options are highlighted, together with minimally invasive surgical procedure. For metastatic affliction, the molecular biology of GIST is reviewed in an in depth and comprehensible demeanour, together with the knowledge that has fostered novel certain ways that experience revolutionized administration. numerous landmark trials were released within the previous couple of years and are positioned in context with admire to present administration. Integration of surgical procedure and systemic treatment via consolidative ways has yielded provocative facts that grants to extra enhance the sphere, and significant advances during this area also are mentioned. Gastrointestinal Stromal Tumors: Bench to Bedside will function a really resource for physicians and researchers facing, and drawn to, this tough malignancy. It offers a concise but entire precis of the present prestige of the sphere that might support advisor sufferer administration and stimulate investigative efforts. All chapters are written through specialists of their fields and comprise the hottest clinical and scientific details.
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Extra resources for Gastrointestinal Stromal Tumors: Bench to Bedside
68. Gill AJ, Chou A, Vilain R, Clarkson A, Lui M, Jin R, et al. Immunohistochemistry for SDHB divides gastrointestinal stromal tumors (GISTs) into 2 distinct types. Am J Surg Pathol. 2010;34:636–44. 69. Matyakhina L, Bei TA, McWhinney SR, Pasini B, Cameron S, Gunawan B, et al. Genetics of Carney triad: recurrent losses at chromosome 1 but lack of germline mutations in genes associated with paragangliomas and gastrointestinal stromal tumors. J Clin Endocrinol Metab. 2007;92:2938–43. 70. Haller F, Moskalev EA, Faucz FR, Barthelmeß S, Wiemann S, Bieg M, et al.
42 O. Cenaj et al. 86. Miettinen M, Wang ZF, Lasota J. DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases. Am J Surg Pathol. 2009;33:1401–8. 87. Liegl B, Hornick JL, Corless CL, Fletcher CD. 1 shows higher sensitivity than KIT in the diagnosis of gastrointestinal stromal tumors, including unusual types. Am J Surg Pathol. 2009;33:437–46. 88. Yamamoto H, Kojima A, Nagata S, Tomita Y, Takahashi S, Oda Y. KIT-negative gastrointestinal stromal tumor of the abdominal soft tissue: a clinicopathologic and genetic study of 10 cases.
The mitotic count is incorporated with primary tumor site and tumor size to determine risk of disease progression, based on data obtained from two large studies (Table 1) [90, 91]. 6 %) Moderate (10 %) None; small number of cases Moderate (16 %) High (55 %) High (86 %) Adapted from Refs. 5 %) Insufficient data High (57 %) High (54 %) High (52 %) Insufficient data High (71 %) Surgical Pathology of Gastrointestinal Stromal Tumors 31 risk-stratification scheme does not apply to SDH-deficient GIST, for which clinical and histologic parameters do not seem to predict risk.
Gastrointestinal Stromal Tumors: Bench to Bedside by Charles R. Scoggins, Chandrajit P. Raut, John T. Mullen