By Nicolas Goossens, Sophie Clément, Francesco Negro
This ebook is a concise and updated evaluate of the medical positive aspects, pathophysiology, analysis, and remedy of sufferers with hepatitis C. Busy future health care pros who desire a speedy overview of hepatitis C and new advancements in remedy for hepatitis C will take advantage of this succinct guide.
Hepatitis C virus basically infects liver cells and will bring about power harm to the liver. sufferers with hepatitis C an infection frequently strengthen liver sequelae resembling fibrosis, cirrhosis, and hepatocellular carcinoma if left untreated. it really is envisioned that a hundred and fifty million humans all over the world are contaminated with hepatitis C virus, and if eradication is to be accomplished it really is vital to diagnose and deal with such individuals.
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Additional resources for Handbook of Hepatitis C
2007;132:667–678. Helle F, Goffard A, Morel V, et al. The neutralizing activity of anti-hepatitis C virus antibodies is modulated by specific glycans on the E2 envelope protein. J Virol. 2007;81:8101–8111. PAT H O P H Y S I O LO G Y • 47 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 Radziewicz H, Ibegbu CC, Hon H, et al. Impaired hepatitis C virus (HCV)-specific effector CD8+ T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection.
Nature. 2008;454:523–527. Li K, Foy E, Ferreon JC, et al. Immune evasion by hepatitis C virus NS3/4A proteasemediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A. 2005;102:2992–2997. Foy E, Li K, Wang C, et al. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science. 2003;300:1145–1148. Lin W, Kim SS, Yeung E, et al. Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain. J Virol.
HCC rarely develops in livers with less fibrosis, although the risk of HCC increases as liver fibrosis progresses. The annual incidence of HCC in patients with established cirrhosis is 1–7% per year . Crucially, despite sustained virological response (SVR) after antiviral therapy, the risk of HCC is reduced but not eliminated, especially in patients with advanced fibrosis . Overall survival As expected, overall survival is decreased in patients with chronic HCV infection, driven in part by increased liver-related deaths .
Handbook of Hepatitis C by Nicolas Goossens, Sophie Clément, Francesco Negro