Regenerative Medicine, Stem Cells and the Liver by David C. Hay PDF

By David C. Hay

ISBN-10: 1578087392

ISBN-13: 9781578087396

The regenerative capability of the liver has been famous for hundreds of years, but if it's crushed through insulting stimuli or is chronically broken, its regenerative power is considerably diminished or misplaced. Researchers were operating to discover recommendations to therapy failing human liver functionality. Given the power of stem cells to self- renew and differentiate into really expert telephone liver forms, they signify an enticing technique to substitute misplaced liver functionality. This ebook starts off by means of outlining the advanced nature of human liver illness and proceeds to check the aptitude that stem cell-based ways need to provide.

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Electrofusion of a mammary gland epithelium cell with an enucleated ewe egg followed by transplantation into a recipient animal was able to give rise to a fully developed live animal whose genetic composition was identical to the donor animal. The successful cloning of the first mouse named Cumulina was in 1998 by Teruhiko Wakayama and colleagues, thus providing the proof of the feasibility of the SCNT (Wakayama et al. 1998). Rigorous efforts 26 Regenerative Medicine, Stem Cells and the Liver succeeded in generating primate ESCs through SCNT, while the generation of human ESCs by SCNT is yet to be done (Byrne et al.

Mol Cell Neurosci. 31: 251–262. Cho HJ, CS Lee, YW Kwon et al. 2010. Induction of pluripotent stem cells from adult somatic cells by protein-based reprogramming without genetic manipulation. Blood. 116: 386–395. Chu K, M Kim, KI Park et al. 2004. Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia. Brain Res. 1016: 145–153. Chu K, M Kim, SW Jeong et al. 2003. Human neural stem cells can migrate, differentiate, and integrate after intravenous transplantation in adult rats with transient forebrain ischemia.

101: 12543–12548. Rangappa S, R Makkar and J Forrester. 2010. Review article: current status of myocardial regeneration: new cell sources and new strategies. J Cardiovasc Pharmacol Ther. 15: 338–343. Reubinoff BE, P Itsykson, T Turetsky et al. 2001. Neural progenitors from human embryonic stem cells. Nature Biotechnology. 19: 1134–1140. Russo FP, MR Alison, BW Bigger et al. 2006. The bone marrow functionally contributes to liver fibrosis. Gastroenterology. 130: 1807–1821. Sacchetti P, KM Sousa, AC Hall et al.

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Regenerative Medicine, Stem Cells and the Liver by David C. Hay


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